6/20/2006 Case 2: Meningeal Rosai-Dorfman disease

Clinical History:

This was another dural based mass lesion, this time from a 23 year old woman, from her left parieto-occipital region. MRI showed this to be an extensive lesion thickening and coating the dura of the left hemisphere extensively.

Diagnostic Notes:

The lesion histologically was a mass of histiocytes, lymphocytes, scattered eosinophils, and occasional plasma cells, all in a moderately vascular fibrous background. There were no lymphoid follicles. There were foamy histiocytes, a few of which contained small dark lymphocyte like-cells suggesting empiripolesis. The histiocytes gave something of a starry sky appearance to portions of the lesion. The lesion appeared to be a case of meningeal Rosai Dorfman Disease.

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